American Endodontic Society
Antibacterial Properties 
Endodontic Sealers

Recently, a study was performed with N2 and other endodontic sealers to show their antibacterial properties.  Parts of the study were published International Endodontic Journal

The study reviewed five commercial endodontic sealers:   Endomethasone N
AH Plus
Apexit Plus

The results of the study indicated that the most intensive antimicrobial activity was noticed in N2 and Endomethasone N, while the lowest was in RoekoSeal.  It concluded that all tested materials increased their antimicrobial activity after the incorporation of antibacterial agents, although the antimicrobial effect declined with time.

It was determined that all of the endodontic sealer materials were found to exhibit antimicrobial properties, with N2 showing the highest antimicrobial effect agains all bacteria.  The most sensitive microorganism was Actynomyces viscous.  The addition of antimicrobials (BC and CPC) increased the antimicrobial effect of all the sealers studied, with significant increases in the zones of inhibition in all cases.  The conclusion was the substances have the potential for use in clinical endodontics in order to maintain the sterile nature of the prepared root canal.  

AES members can receive a copy of the complete study by 
e-mailing their request to